Clinical Trials Results
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Trial Name
Brief Summary
This randomized phase III trial studies radiation therapy with chemotherapy to see how well
they work compared to radiation therapy alone in treating patients with stage I-IIA cervical
cancer who previously underwent surgery. Radiation therapy uses high-energy x-rays to kill
tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop
the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. It is not yet known whether giving radiation therapy together
with chemotherapy is more effective than radiation therapy alone in treating patients with
cervical cancer.
This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral
salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1
mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and
bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and
ovaries. This study may help doctors determine if the two surgical procedures are nearly the
same for ovarian cancer risk reduction for women with BRCA1 mutations.
This randomized phase II/III trial studies how well cediranib maleate and olaparib work when
given together or separately, and compares them to standard chemotherapy in treating patients
with ovarian, fallopian tube, or primary peritoneal cancer that has returned (recurrent)
after receiving chemotherapy with drugs that contain platinum (platinum-resistant) or
continued to grow while being treated with platinum-based chemotherapy drugs
(platinum-refractory). Cediranib maleate and olaparib may stop the growth of tumor cells by
blocking enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to
stop the growth of tumor cells, either by killing the cells, by stopping them from dividing,
or by stopping them from spreading. It is not yet known whether giving cediranib maleate and
olaparib together may cause more damage to cancer cells when compared to either drug alone or
standard chemotherapy.
This randomized phase III trial studies radiation therapy and cisplatin with triapine to see
how well they work compared to the standard radiation therapy and cisplatin alone in treating
patients with newly diagnosed stage IB2, II, or IIIB-IVA cervical cancer or stage II-IVA
vaginal cancer. Radiation therapy uses high energy protons to kill tumor cells and shrink
tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the
growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. Triapine may stop the growth of tumor cells by blocking some of
the enzymes needed for cell growth. It is not yet known whether radiation therapy and
cisplatin are more effective with triapine in treating cervical or vaginal cancer.
This phase II/III trial studies how well pegylated liposomal doxorubicin hydrochloride with
atezolizumab and/or bevacizumab work in treating patients with ovarian, fallopian tube, or
primary peritoneal cancer that has come back (recurrent). Drugs used in chemotherapy, such as
pegylated liposomal doxorubicin hydrochloride, work in different ways to stop the growth of
cancer cells, either by killing the cells, by stopping them from dividing, or by stopping
them from spreading. Immunotherapy with monoclonal antibodies, such as atezolizumab and
bevacizumab, may help the body's immune system attack the cancer, and may interfere with the
ability of tumor cells to grow and spread. It is not yet known which combination will work
better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer.
This phase II trial studies how well olaparib and cediranib maleate work in treating patients
with endometrial cancer that has come back, does not respond to treatment, or has spread to
other places in the body. Olaparib and cediranib maleate may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth.
This phase II trial studies how well tazemetostat works in treating patients with ovarian,
primary peritoneal, or endometrial cancer that has come back. Drugs used in chemotherapy,
such as tazemetostat, work in different ways to stop the growth of tumor cells, either by
killing the cells, by stopping them from dividing, or by stopping them from spreading.
This phase II trial studies how well pembrolizumab and epacadostat work in treating patients
with ovarian clear cell carcinoma that has come back, remains despite treatment, or is
growing, spreading, or getting worse. Immunotherapy with monoclonal antibodies, such as
pembrolizumab, may help the body's immune system attack the cancer, and may interfere with
the ability of tumor cells to grow and spread. Epacadostat may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth. Giving pembrolizumab and epacadostat
may work better in treating patients with ovarian clear cell carcinoma.
This phase III trial studies how well the combination of pembrolizumab, paclitaxel and
carboplatin, works compared with paclitaxel and carboplatin alone in treating patients with
endometrial cancer that is stage III or IV, or has come back (recurrent). Immunotherapy with
monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the
cancer, and may interfere with the ability of tumor cells to grow and spread. Paclitaxel and
carboplatin are chemotherapy drugs used as part of the usual treatment approach for this type
of cancer. This study aims to assess if adding immunotherapy to these drugs is better or
worse than the usual approach for treatment of this cancer.
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin
works in treating patients with stage II-IV low-grade serous carcinoma of the ovary or
peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the
body which in turn may stop the growth of tumor cells that need estrogen to grow. Drugs used
in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the
growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. It is not yet known whether giving letrozole alone or in
combination with paclitaxel and carboplatin works better in treating patients with low-grade
serous carcinoma of the ovary or peritoneum compared to paclitaxel and carboplatin without
letrozole.
This phase III trial compares whether the addition of pembrolizumab to radiation therapy is
more effective than radiation therapy alone in reducing the risk of cancer coming back
(recurrence) in patients with newly diagnosed stage I-II endometrial cancer. Immunotherapy
with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack
the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation
therapy uses high energy x-rays to kill tumor cells and shrink tumors. The addition of
pembrolizumab to radiation treatment may be more effective than radiation treatment alone in
reducing cancer recurrence.
Clinical Trial Categories:
- Bone Cancer
- Brain Cancer
- Breast Cancer
- Cancer Control
- Companion Studies
- Gastrointestinal Cancer
- Genitourinary Cancer
- Gynecology (GYN) Cancer
- Head and Neck Cancer
- Leukemia
- Lung Cancer
- Lymphoma (Hodgkin's Disease, Non-Hodgkin's Lymphoma)
- Melanoma
- Multiple Myeloma
- Myelodysplastic Syndrome (MDS)
- Other Cancer Protocols
- Pancreas Cancer
- Sarcoma
- Skin Cancer
- Symptom Management