Clinical Trials Results
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Trial Name
Brief Summary
This trial studies the side effects of pembrolizumab with or without chemotherapy in treating
patients with stage IV non-small cell lung cancer that has come back (recurrent) and has
spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such
as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with
the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as pemetrexed
and carboplatin, work in different ways to stop the growth of tumor cells, either by killing
the cells, by stopping them from dividing, or by stopping them from spreading. Giving
pembrolizumab with or without chemotherapy may shrink the tumor in older patients with
non-small cell lung cancer.
This phase III trial compares an additional support program (text message reminders and/or
telephone-based counseling) with usual care in making sure breast cancer patients take their
endocrine therapy medication as prescribed (medication adherence). Medication adherence is
how well patients take the medication as prescribed by their doctors, and good medical
adherence is when patients take medications correctly. Poor medication adherence has been
shown to be a serious barrier to effective treatment for hormone receptor positive breast
cancer patients. Adding text message reminders and/or telephone-based counseling to usual
care may increase the number of days that patients take their endocrine therapy medication as
prescribed.
This randomized phase III trial studies metformin hydrochloride to see how well it works
compared to placebo in preventing breast cancer in patients with atypical hyperplasia or in
situ breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
The use of metformin hydrochloride may prevent breast cancer.
This randomized phase III trial studies how well hypofractionated radiation therapy works in
preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy.
Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter
period of time and may kill more tumor cells that remain after surgery and have fewer side
effects.
This clinical trial studies reproductive health program in patients with cancer. A
reproductive health program may improve patients' understanding of reproductive risks and
receipt of appropriate treatment to achieve their reproductive health goals
This randomized phase III trial studies digital tomosynthesis mammography and digital
mammography in screening patients for breast cancer. Screening for breast cancer with
tomosynthesis mammography may be superior to digital mammography for breast cancer screening
and may help reduce the need for additional imaging or treatment.
This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work
in treating patients with pneumonitis that does not respond to steroid treatment.
Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's
immune system and may interfere with the ability of tumor cells to grow and spread.
Intravenous immunoglobulin therapy may improve pneumonitis. It is not yet known whether
giving infliximab and intravenous immunoglobulin therapy will work better in treating
patients with pneumonitis.
This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral
salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1
mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and
bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and
ovaries. This study may help doctors determine if the two surgical procedures are nearly the
same for ovarian cancer risk reduction for women with BRCA1 mutations.
This phase III trial studies how well tenofovir alafenamide works in preventing liver
complications in participants with current or past hepatitis B virus (HBV) who are receiving
anti-cancer therapy for solid tumors. People with chronic or past HBV who are undergoing
therapy for cancer are at an increased risk for changes in the liver which could be minor or
severe. Tenofovir alafenamide is a drug that acts against infections caused by HBV and may
help reduce the chance that HBV gets worse or comes back in participants receiving
anti-cancer therapy for solid tumors.
This trial studies the implementation of decision support tools integrated into the
electronic health record and patient portal for patients with atypical hyperplasia or lobular
carcinoma in situ and healthcare providers. Decision support tools are designed to improve
informed choice about breast cancer chemoprevention. Recognizing barriers and facilitators
that can influence the adoption of decision support tools at recruitment centers may help
researchers learn how to best implement them into clinical practice.
This phase II trial studies the effects of transcutaneous electrical nerve stimulation (TENS)
for the treatment of peripheral neuropathy caused by chemotherapy, often called
chemotherapy-induced peripheral neuropathy (CIPN). Peripheral neuropathy refers to the
conditions that result when nerves that carry messages to and from the brain and spinal cord
from and to the rest of the body are damaged or diseased. The TENS device emits high
frequency electrical stimulation through the skin and may provide relief from chronic pain.
This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and
dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron
hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in
patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may
help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.
This study is being done to see if patients receiving chemotherapy for breast cancer affects
the heart, the ability to exercise and fatigue when compared to patients who do not have
cancer.
Clinical Trial Categories:
- Bone Cancer
- Brain Cancer
- Breast Cancer
- Cancer Control
- Companion Studies
- Gastrointestinal Cancer
- Genitourinary Cancer
- Gynecology (GYN) Cancer
- Head and Neck Cancer
- Leukemia
- Lung Cancer
- Lymphoma (Hodgkin's Disease, Non-Hodgkin's Lymphoma)
- Melanoma
- Multiple Myeloma
- Myelodysplastic Syndrome (MDS)
- Other Cancer Protocols
- Pancreas Cancer
- Sarcoma
- Skin Cancer
- Symptom Management