Clinical Trials Results
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Trial Name
Brief Summary
This randomized phase III trial studies metformin hydrochloride to see how well it works
compared to placebo in preventing breast cancer in patients with atypical hyperplasia or in
situ breast cancer. Chemoprevention is the use of certain drugs to keep cancer from forming.
The use of metformin hydrochloride may prevent breast cancer.
This randomized pilot clinical trial studies the side effects and best dose of naloxegol and
to see how well it works in treating patients with stage IIIB-IV non-small cell lung cancer.
Naloxegol may relieve some of the side effects of opioid pain medication and fight off future
growth in the cancer.
This randomized phase III trial studies how well hypofractionated radiation therapy works in
preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy.
Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter
period of time and may kill more tumor cells that remain after surgery and have fewer side
effects.
This clinical trial studies reproductive health program in patients with cancer. A
reproductive health program may improve patients' understanding of reproductive risks and
receipt of appropriate treatment to achieve their reproductive health goals
This randomized phase III trial studies digital tomosynthesis mammography and digital
mammography in screening patients for breast cancer. Screening for breast cancer with
tomosynthesis mammography may be superior to digital mammography for breast cancer screening
and may help reduce the need for additional imaging or treatment.
This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral
salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1
mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and
bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and
ovaries. This study may help doctors determine if the two surgical procedures are nearly the
same for ovarian cancer risk reduction for women with BRCA1 mutations.
This phase III trial studies how well tenofovir alafenamide works in preventing liver
complications in participants with current or past hepatitis B virus (HBV) who are receiving
anti-cancer therapy for solid tumors. People with chronic or past HBV who are undergoing
therapy for cancer are at an increased risk for changes in the liver which could be minor or
severe. Tenofovir alafenamide is a drug that acts against infections caused by HBV and may
help reduce the chance that HBV gets worse or comes back in participants receiving
anti-cancer therapy for solid tumors.
This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and
dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron
hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in
patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may
help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.
To document levels of labor force participation, occupation, educational attainment, and
financial toxicity following cancer treatment in YA cancer survivors aged 25-34 years.
This study is being done to see if patients receiving chemotherapy for breast cancer affects
the heart, the ability to exercise and fatigue when compared to patients who do not have
cancer.
Clinical Trial Categories:
- Bone Cancer
- Brain Cancer
- Breast Cancer
- Cancer Control
- Companion Studies
- Gastrointestinal Cancer
- Genitourinary Cancer
- Gynecology (GYN) Cancer
- Head and Neck Cancer
- Leukemia
- Lung Cancer
- Lymphoma (Hodgkin's Disease, Non-Hodgkin's Lymphoma)
- Melanoma
- Multiple Myeloma
- Myelodysplastic Syndrome (MDS)
- Other Cancer Protocols
- Pancreas Cancer
- Sarcoma
- Skin Cancer
- Symptom Management