Clinical Trials Results
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This trial studies the side effects of pembrolizumab with or without chemotherapy in treating
patients with stage IV non-small cell lung cancer that has come back (recurrent) and has
spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such
as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with
the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as pemetrexed
and carboplatin, work in different ways to stop the growth of tumor cells, either by killing
the cells, by stopping them from dividing, or by stopping them from spreading. Giving
pembrolizumab with or without chemotherapy may shrink the tumor in older patients with
non-small cell lung cancer.
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This phase III trial compares an additional support program (text message reminders and/or
telephone-based counseling) with usual care in making sure breast cancer patients take their
endocrine therapy medication as prescribed (medication adherence). Medication adherence is
how well patients take the medication as prescribed by their doctors, and good medical
adherence is when patients take medications correctly. Poor medication adherence has been
shown to be a serious barrier to effective treatment for hormone receptor positive breast
cancer patients. Adding text message reminders and/or telephone-based counseling to usual
care may increase the number of days that patients take their endocrine therapy medication as
prescribed.
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This phase III trial compares denosumab to placebo for the prevention of breast cancer in
women with a BRCA1 germline mutation. A germline mutation is an inherited gene change which,
in the BRCA1 gene, is associated with an increased risk of breast and other cancers.
Denosumab is a monoclonal antibody that is used to treat bone loss in order to reduce the
risk of bone fractures in healthy people, and to reduce new bone growths in cancer patients
whose cancer has spread to their bones. Research has shown that denosumab may also reduce the
risk of developing breast cancer in women carrying a BRCA1 germline mutation.
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This phase III trial compares the effect of text-based cessation intervention to a manual in
helping rural cancer patients who smoke, quit. Text-based scheduled gradual reduction may
reduce the frequency of cigarette use to zero and may be effective in quitting smoking.
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This phase III trial studies how well Mepitel Film works in reducing radiation dermatitis
(redness and peeling) in patients with breast cancer during radiation therapy after a
mastectomy. Mepitel Film may reduce the severity of skin redness and peeling in the area of
radiation.
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This phase II trial compares the effect of oxybutynin versus placebo for reducing hot flashes
in men receiving androgen deprivation (hormone) therapy for the treatment of prostate cancer
. Androgen deprivation therapy decreases testosterone and other androgens through medications
or surgical removal of the testicles. Relative to placebo, low- or high-dose oxybutynin may
reduce hot flashes in men receiving androgen deprivation therapy.
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This phase III trial compares the effects of olanzapine versus megestrol acetate in treating
loss of appetite in patients with cancer that has spread to other places in the body
(advanced). Olanzapine may stimulate and increase appetite. This study aims to find out if
olanzapine is better than the usual approach (megestrol acetate) for stimulating appetite and
preventing weight loss.
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This clinical trial studies reproductive health program in patients with cancer. A
reproductive health program may improve patients' understanding of reproductive risks and
receipt of appropriate treatment to achieve their reproductive health goals
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This randomized phase III trial studies digital tomosynthesis mammography and digital
mammography in screening patients for breast cancer. Screening for breast cancer with
tomosynthesis mammography may be superior to digital mammography for breast cancer screening
and may help reduce the need for additional imaging or treatment.
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The purpose of this study is to compare the two approaches for monitoring pancreatic cysts.
The study doctors want to compare more frequent monitoring vs less frequent monitoring in
order to learn which monitoring method leads to better outcome for patients with pancreatic
cysts.
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This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work
in treating patients with pneumonitis that does not respond to steroid treatment.
Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's
immune system and may interfere with the ability of tumor cells to grow and spread.
Intravenous immunoglobulin therapy may improve pneumonitis. It is not yet known whether
giving infliximab and intravenous immunoglobulin therapy will work better in treating
patients with pneumonitis.
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The purpose of this study is to evaluate feasibility and acceptability of completing PROs
among AYAs randomized to Choice PRO vs Fixed PRO.
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This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced
adenomas randomized to surveillance colonoscopy at 10 years compared to participants
randomized to surveillance colonoscopy at 5 and 10 years.
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This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral
salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1
mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and
bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and
ovaries. This study may help doctors determine if the two surgical procedures are nearly the
same for ovarian cancer risk reduction for women with BRCA1 mutations.
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This trial studies the implementation of decision support tools integrated into the
electronic health record and patient portal for patients with atypical hyperplasia or lobular
carcinoma in situ and healthcare providers. Decision support tools are designed to improve
informed choice about breast cancer chemoprevention. Recognizing barriers and facilitators
that can influence the adoption of decision support tools at recruitment centers may help
researchers learn how to best implement them into clinical practice.
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This study examines how certain risk factors (such as age, gender, other medical conditions,
and the type of immunotherapy used to treat the cancer) affect whether a patient with a
malignant solid tumor will develop mild or serious side effects from the immunotherapy
medications. Immunotherapy is the type of treatment that helps the body's immune system fight
cancer. In the future, this information may help doctors make better decisions about cancer
treatments.
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This randomized phase III trial studies how well netupitant/palonosetron hydrochloride and
dexamethasone with prochlorperazine or olanzapine work compared to netupitant/palonosetron
hydrochloride and dexamethasone in improving chemotherapy-induced nausea and vomiting in
patients with breast cancer. Antiemetic drugs, such as prochlorperazine and olanzapine, may
help lessen nausea and vomiting in patients with breast cancer treated with chemotherapy.
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This phase III trial compares the effect of geriatric evaluation and management with
survivorship health education (GEMS) to usual care on patient-reported physical function in
older survivors of cancer. Survivorship care for older adults of cancer usually consists of
getting advice from their doctor. This advice may include how to do their daily activities,
so they are less tired or how to manage multiple diseases, or long-term side effects from
treatment. GEMS may help improve the physical ability to perform activities of daily living,
mental well-being, and memory in older survivors of cancer after chemotherapy. This study may
help doctors learn if including GEMS in their practices improves physical, mental and memory
functions in their patients. The study may also help to understand how such care affects
cancer patients and their caregivers' quality of life.
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This phase III trial compares the effect of geriatric evaluation and management with
survivorship health education (GEMS) to usual care on patient-reported physical function in
older survivors of cancer. Survivorship care for older adults of cancer usually consists of
getting advice from their doctor. This advice may include how to do their daily activities,
so they are less tired or how to manage multiple diseases, or long-term side effects from
treatment. GEMS may help improve the physical ability to perform activities of daily living,
mental well-being, and memory in older survivors of cancer after chemotherapy. This study may
help doctors learn if including GEMS in their practices improves physical, mental and memory
functions in their patients. The study may also help to understand how such care affects
cancer patients and their caregivers' quality of life.
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This phase III trial compares BBT-CI to HEAL for the reduction of insomnia in patients with
stage I-III cancer who are receiving chemotherapy. Chemotherapy can cause side effects such
as sleep problems. Sleep problems such as insomnia, are common for cancer patients. Insomnia
can be described as difficulty falling asleep, waking up many times during the night or
waking up earlier than patient would like. Insomnia can increase fatigue and worsen quality
of life. This trial may help researchers determine which treatment works better in reducing
insomnia, BBT-CI or HEAL.
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