Clinical Trials Results
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Trial Name
Brief Summary
This randomized phase III trial studies how well initial treatment with ipilimumab and
nivolumab followed by dabrafenib and trametinib works and compares it to initial treatment
with dabrafenib and trametinib followed by ipilimumab and nivolumab in treating patients with
stage III-IV melanoma that contains a mutation known as BRAFV600 and cannot be removed by
surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and
nivolumab, may help the body's immune system attack the cancer, and may interfere with the
ability of tumor cells to grow and spread. Dabrafenib and trametinib may block tumor growth
by targeting the BRAFV600 gene. It is not yet known whether treating patients with ipilimumab
and nivolumab followed by dabrafenib and trametinib is more effective than treatment with
dabrafenib and trametinib followed by ipilimumab and nivolumab.
This randomized phase II/III trial studies the side effects and best dose of nivolumab and
ipilimumab when given together with or without sargramostim and to see how well they work in
treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal
antibodies, such as ipilimumab and nivolumab, may kill tumor cells by blocking blood flow to
the tumor, by stimulating white blood cells to kill the tumor cells, or by attacking specific
tumor cells and stop them from growing or kill them. Colony-stimulating factors, such as
sargramostim, may increase the production of white blood cells. It is not yet known whether
nivolumab and ipilimumab are more effective with or without sargramostim in treating patients
with melanoma.
This phase II trial studies how well encorafenib and binimetinib work before surgery in
treating patients with BRAF V600-mutated stage IIIB-D melanoma that has spread to the lymph
nodes. Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the
enzymes needed for cell growth. This trial also studies how well 18F-FLT positron emission
tomography (PET)/computed tomography (CT) works in predicting the response of melanoma to
encorafenib and binimetinib. 18F-FLT is an imaging agent, sometimes called a tracer. PET and
CT are types of imaging scans. Using 18F-FLT PET/CT together with encorafenib and binimetinib
may provide more information on melanoma over time.
This pilot phase II trial studies how well pembrolizumab works in treating patients with
desmoplastic melanoma (DM) that can or cannot be removed by surgery (unresectable).
Monoclonal antibodies, like pembrolizumab, may block specific proteins which may strengthen
the immune system and control tumor growth.
This phase II trial studies how well talimogene laherparepvec and pembrolizumab work in
treating patients with stage III-IV melanoma. Biological therapies, such as talimogene
laherparepvec, use substances made from living organisms that may stimulate or suppress the
immune system in different ways and stop tumor cells from growing. Immunotherapy with
monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the
cancer, and may interfere with the ability of tumor cells to grow and spread. Giving
talimogene laherparepvec and pembrolizumab may work better in treating patients with melanoma
by shrinking the tumor.
This phase II trial studies how well ipilimumab with or without nivolumab work in treating
patients with melanoma that is stage IV or stage III and cannot be removed by surgery.
Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the
body's immune system attack the cancer, and may interfere with the ability of tumor cells to
grow and spread.
Clinical Trial Categories:
- Bone Cancer
- Brain Cancer
- Breast Cancer
- Cancer Control
- Companion Studies
- Gastrointestinal Cancer
- Genitourinary Cancer
- Gynecology (GYN) Cancer
- Head and Neck Cancer
- Leukemia
- Lung Cancer
- Lymphoma (Hodgkin's Disease, Non-Hodgkin's Lymphoma)
- Melanoma
- Multiple Myeloma
- Myelodysplastic Syndrome (MDS)
- Other Cancer Protocols
- Pancreas Cancer
- Sarcoma
- Skin Cancer
- Symptom Management